Negative effect of vitamin D on kidney function: a Mendelian randomization study.

ABSTRACT:

Background

The kidney plays a central role in the regulation of vitamin D metabolism. It is not clear, however, whether vitamin D influences kidney function. Previous studies have reported conflicting results, which may have been influenced by reverse causation and residual confounding. We conducted a Mendelian randomization (MR) study to obtain unconfounded estimates of the association between genetically instrumented vitamin D metabolites and estimated glomerular filtration rate (eGFR) as well as the urinary albumin:creatinine ratio (UACR).

Methods

We performed a two-sample MR study based on three single nucleotide variants associated with 25(OH)D levels: rs2282679, rs10741657 and rs12785878, related to the genes GC, CYP2R1 and DHCR7, respectively. Estimates of the allele-

SUBMITTER: Teumer A 

PROVIDER: S-EPMC6275146 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature