Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats.

ABSTRACT: Triclosan, a widely used industrial and household agent, is present as an antiseptic ingredient in numerous products of everyday use, such as toothpaste, cosmetics, kitchenware, and toys. Previous studies have shown that human brain and animal tissues contain triclosan, which has been found also as a contaminant of water and soil. Triclosan disrupts heart and skeletal muscle Ca²⁺ signaling, damages liver function, alters gut microbiota, causes colonic inflammation, and promotes apoptosis in cultured neocortical neurons and neural stem cells. Information, however, on the possible effects of triclosan on the function of the hippocampus, a key brain region for spatial learning and memory, is lacking. Here, we report that triclosan addition at low concentrations to hippocampal slice

SUBMITTER: Arias-Cavieres A 

PROVIDER: S-EPMC6275195 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature