Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network.

ABSTRACT: Tanycytes are hypothalamic radial glia-like cells that form the basal wall of the third ventricle (3V) where they sense glucose and modulate neighboring neuronal activity to control feeding behavior. This role requires the coupling of hypothalamic cells since transient decreased hypothalamic Cx43 expression inhibits the increase of brain glucose-induced insulin secretion. Tanycytes have been postulated as possible hypothalamic neuronal precursors due to their privileged position in the hypothalamus that allows them to detect mitogenic signals and because they share the markers and characteristics of neuronal precursors located in other neurogenic niches, including the formation of coupled networks through connexins. Using wild-type (WT), Cx30^-/- and Cx30^-/-, Cx43

SUBMITTER: Recabal A 

PROVIDER: S-EPMC6275304 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature