Peritoneal dialysis fluid biocompatibility impact on human peritoneal membrane permeability.

ABSTRACT:

Background

We have compared the effects of conventional lactate-based peritoneal dialysis fluid (CPDF) with respect to bicarbonate/lactate-based fluid on peritoneal ultrafiltration (UF) and peritoneal permeability, and on variations on gene expression in cells isolated from effluents of patients' peritoneal bags.

Methods

This was a non-randomized sequential prospective study including all incident peritoneal dialysis (PD) patients (n = 40) recruited in our centre. Peritoneal equilibration tests (PETs) were performed using CPDF or BPDF both containing 2.27% glucose during a 48-h interval in four different sequences. Gene expression variation of selected genes was measured by reverse transcription polymerase chain reaction in mesothelial cells obtained from the total dr

SUBMITTER: Rodriguez-Esparragon F 

PROVIDER: S-EPMC6275447 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature