Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

ABSTRACT: Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expre

SUBMITTER: Doupe DP 

PROVIDER: S-EPMC6275525 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature