Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease.

ABSTRACT:

Aim

Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients.

Methods

Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain.

Results & conclusion

We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models

SUBMITTER: Jhun EH 

PROVIDER: S-EPMC6275563 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature