Increased risk of recurrence in resected EGFR-positive pN0M0 invasive lung adenocarcinoma.

ABSTRACT:

Background

This study was conducted to evaluate the prognostic and recurrent impact of EGFR mutation status in resected pN0M0 lung adenocarcinoma with consideration of the histological subtype.

Methods

Following retrospective analysis of whole 474 consecutive pathological N0M0 lung adenocarcinoma patients, the prognostic significance of EGFR mutation status was evaluated in limited 394 subjects. Overall survival and recurrence-free interval (RFI) were estimated using the Kaplan-Meier method and compared using a log-rank test. Univariate and multivariate analyses were performed using Cox proportional hazard models.

Results

The five-year RFI was 85.7% and 93.3% for EGFR positive (n = 176) and negative (n = 218) cases, respectively (hazard ratio [HR] 1.992, 95% confidenc

SUBMITTER: Ito M 

PROVIDER: S-EPMC6275825 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature