Genetic analyses of differences between solid and nonsolid predominant lung adenocarcinomas.

ABSTRACT:

Background

Solid predominant lung adenocarcinomas (LUAD) have distinct histopathological and clinical characteristics compared with nonsolid subtypes. A comprehensive comparison of altered genes found in solid and nonsolid subtypes has not previously been performed. In this study, we analyzed differences in gene expression, genetic mutations, and DNA methylation to better understand the risk factors for these two subtypes of LUAD.

Methods

Differentially expressed genes (DEGs) and differentially mutated genes (DMGs) were analyzed from RNA-seq data downloaded from The Cancer Genome Atlas (TCGA) and Broad Institute database. To understand the functional significance of molecular changes, we examined the DEGs and DMGs with Gene Ontology and Kyoto Encyclopedia of Genes and Genome

SUBMITTER: Luo J 

PROVIDER: S-EPMC6275839 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature