Up-regulation of GluN2A-containing NMDA receptor protects cultured cortical neuron cells from oxidative stress.

ABSTRACT: Neuronal excitotoxicity induced by spreading depolarization occurs during multiple brain diseases. The subsequent extensive releasing of neuronal transmitter glutamate results in over activation of the ionic glutamate receptors and then triggers neuronal cell death. The N-methyl-D-aspartate (NMDA) receptor is one major type of excitatory ionic glutamate receptors in the central nervous system, and it exerts vital functions on the membrane of neurons. Distinct subtypes of the NMDA receptor play different roles and their expression was dynamically regulated according to both physiological and pathological stimulations. During neuronal excitotoxicity the expression of the GluN2A-containing NMDA receptor is specifically up-regulated, and as a result, the ratio of GluN2A- versus GluN2B-containi

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6275848 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature