Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6275976 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
Li Hongyan H Tong Shaoming S Liu Jiwei J Han Li L Yang Xuesong X Hou Hesheng H Yan Qiu Q Wang Xiao-Qi XQ
Cellular & molecular biology letters 20120601 2
Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expressi ...[more]
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