Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state.

ABSTRACT: Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to assess the efficacy of therapies aimed to reduce the tissue damaging activities of microglia and/or to promote the protective potential of these cells, suitable pre-clinical and clinical tools for the in vivo analysis of microglia activities and dynamics are required. The aim of this work was to identify new translational markers of the anti-inflammatory / protective state of microglia for the development of novel PET tracers. Methods: New translational markers of the anti-inflammatory/protective activation state of microglia were selected by bioinformatic approaches and were in vitro and ex vivo validated

SUBMITTER: Villa A 

PROVIDER: S-EPMC6276082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature