Prostaglandin E₂ hydrogel improves cutaneous wound healing via M2 macrophages polarization.

ABSTRACT: Wound healing is regulated by a complex series of events and overlapping phases. A delicate balance of cytokines and mediators in tissue repair is required for optimal therapy in clinical applications. Molecular imaging technologies, with their versatility in monitoring cellular and molecular events in living organisms, offer tangible options to better guide tissue repair by regulating the balance of cytokines and mediators at injured sites. Methods: A murine cutaneous wound healing model was developed to investigate if incorporation of prostaglandin E₂ (PGE₂) into chitosan (CS) hydrogel (CS+PGE₂ hydrogel) could enhance its therapeutic effects. Bioluminescence imaging (BLI) was used to noninvasively monitor the inflammation and angiogenesis processes

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6276096 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature