Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies.

ABSTRACT:

Background

Folate receptors (FRs) facilitate embryonic uptake of folates and are important for proper early embryonic development. There is accumulating evidence that blocking FR autoantibodies contribute to developmental diseases. However, genetic factors associated with the expression of FR autoantibodies remain unknown.

Objective

We investigated the effects of genetic polymorphisms in folate pathway genes on FR autoantibody titers in women.

Methods

We recruited 302 pregnant women in China. The FR antigen-down immunoassay was used to measure levels of FR autoantibodies including human immunoglobulin G (IgG) and immunoglobulin M (IgM) in maternal plasma. Genotypes were identified by matrix-assisted laser desorption/ionization time of flight mass spectrometry and poly

SUBMITTER: Dong Y 

PROVIDER: S-EPMC6276117 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature