Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

ABSTRACT:

Background & aims

There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls).

Methods

We studied subjects with metabolic syndrome and/or levels of alanine aminotransferase and aspartate aminotransferase >30 mU/L, using magnetic resonance spectroscopy to identify those with high levels (HighLF, n = 13) or low levels (LowLF, n = 11) of liver fat. Clinical and demographic information was collected from all participants, and insulin sensitivity was measured using the insulin-modified intravenous glucose tolerance test. Stable isotopes were administere

SUBMITTER: Lambert JE 

PROVIDER: S-EPMC6276362 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature