Predictive Value of Two Polymorphisms of ERCC2, rs13181 and rs1799793, in Clinical Outcomes of Chemotherapy in Gastric Cancer Patients: A Meta-Analysis.

ABSTRACT:

Background

Several researchers have investigated the relationship between ERCC2 rs13181 and rs1799793 polymorphisms and chemotherapy efficacy in terms of tumour response and prognosis in gastric patients. However, the published data have shown inconsistencies.

Methods

PubMed, Elsevier, and Chinese National Knowledge Infrastructure databases were searched for relevant articles published before August 1, 2017. Thirteen studies including 3096 gastric cancer patients treated with chemotherapy were included.

Results

For rs1799793, in the overall analyses, no relationships were found between four genetic models and clinical response (AA vs. GG: OR = 1.17, 95% CI, 0.70-1.95; GA vs. GG: OR = 0.94, 95% CI, 0.69-1.27; GA + AA vs. GG: OR = 1.12, 95% CI, 0.85-1.46; and AA vs. GG 

SUBMITTER: Li M 

PROVIDER: S-EPMC6276480 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature