The usefulness of soluble receptor for advanced glycation end-products in the identification of COPD frequent exacerbator phenotype.

ABSTRACT: Introduction:Exacerbations of COPD (ECOPDs) are important events in the course of COPD, accelerating the rate of decline in lung function and increasing the mortality risk. A growing body of evidence suggests the significance of the "frequent exacerbator" phenotype. This phenotype seems to be associated with a more severe airflow limitation, symptoms, health-related quality of life impairment, and higher mortality. However, there is no described biomarker that would help to identify this group of patients. Patients and methods:Patients with COPD in "D" GOLD category were monitored for 3 years according to events of ECOPD. Serum samples were collected from the patients. Circulating level of plasma soluble receptor for advanced glycation end-products (sRAGE) was measured using commercially a

SUBMITTER: Milkowska-Dymanowska J 

PROVIDER: S-EPMC6276626 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature