Endometrial receptivity enhancement through induced injury and repair during ovarian stimulation: the Receptivity Enhancement by Follicular-phase Renewal after Endometrial ScratcHing (REFRESH) trial protocol.

ABSTRACT:

Study question

Does intentional endometrial injury (i.e. endometrial scratching) during ART enhance pregnancy rates?

Summary answer

We propose a randomized controlled clinical trial in women performing ART in which the intervention group will undergo an additional endometrial biopsy during exogenous ovarian stimulation.

What is known already

Although endometrial receptivity has been extensively studied, the mechanisms behind the implantation of an embryo remain largely a mystery. Intentional endometrial injury has been put forward by many researchers as an inexpensive clinical tool capable of enhancing endometrial receptivity. However, despite its widespread use, the benefit of endometrial scratching is still a contentious and unresolved issue.

Study design size du

SUBMITTER: Santos-Ribeiro S 

PROVIDER: S-EPMC6276659 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature