Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.

ABSTRACT:

Context

The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as the related acylethanolamide oleoylethanolamide (OEA), have been implicated in energy expenditure (EE) regulation and metabolic diseases. Muscle (fat-free mass) and fat (fat mass) are metabolically active compartments and main determinants of EE.

Objective

To assess whether human muscle, adipose, and plasma endocannabinoids correlate with EE.

Design

Muscle, adipose, and plasma AEA, 2-AG, and OEA concentrations were measured via liquid chromatography-mass spectrometry. EE was assessed by indirect whole-room calorimetry.

Setting

Clinical trial.

Participants

Obese/overweight Native Americans of full (n = 35) and at least half (n = 21) Southwestern heritage.

Main o

SUBMITTER: Heinitz S 

PROVIDER: S-EPMC6276675 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature