An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.

ABSTRACT:

Study question

Are the single nucleotide polymorphisms (SNPs) rs2075230, rs6259 and rs727428 at the sex hormone-binding globulin (SHBG) locus, which were identified by genome-wide association studies (GWASs) for testosterone levels, associated with testosterone levels in Japanese men?

Summary answer

The SNP rs2075230, but not rs6259 and rs727428, is significantly associated with testosterone levels in Japanese men.

What is already known

Previous GWASs have revealed that rs2075230 is associated with serum testosterone levels in 3495 Chinese men and rs6259 and rs727428 are associated with serum testosterone levels in 3225 men of European ancestry.

Study design size and duration

This is an independent validation study of 1687 Japanese men (901 in Cohort 1 a

SUBMITTER: Sato Y 

PROVIDER: S-EPMC6276698 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature