Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2.

ABSTRACT:

Context

Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet, regulation of endometrial carbohydrate metabolism is poorly characterized. Whereas glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of the insulin receptor is maximally expressed in secretory-phase endometrium, indicating a potential role of insulin in glucose metabolism.

Objective

We sought to determine whether insulin or progesterone regulates glycogen synthesis in human endometrium.

Design, participants, outcome measurements

Endometrial epithelial cells were isolated from 28 healthy women and treated with insulin, medroxyprogesterone (MPA), or vehicle. Intracellul

SUBMITTER: Flannery CA 

PROVIDER: S-EPMC6276707 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature