Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis.

ABSTRACT: Context:With the aging of the population and projected increase in osteoporotic fractures coupled with the declining use of osteoporosis medications, there is a compelling need for new approaches to treat osteoporosis. Given that age-related osteoporosis generally coexists with multiple other comorbidities (e.g., atherosclerosis, diabetes, frailty) that share aging as the leading risk factor, there is growing interest in the "Geroscience Hypothesis," which posits that manipulation of fundamental aging mechanisms will delay the appearance or severity of multiple chronic diseases because these diseases share aging as the underlying risk factor. In this context, one fundamental aging mechanism that has received considerable attention recently as contributing to multiple age-related morbiditie

SUBMITTER: Khosla S 

PROVIDER: S-EPMC6276719 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature