Study of Deiodinase Type 2 Polymorphisms in Graves' Disease and Ophthalmopathy in a Swedish Population.

ABSTRACT:

Background

Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association of SNPs in DIO2 with Graves' disease (GD) was suggested in 2 Russian studies.

Objectives

The aim of the study was to examine whether SNPs in DIO2 are associated with GD or Graves' ophthalmopathy (GO).

Methods

Seven SNPs in the DIO2 gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995, rs225015, and rs2267873 - were studied to assess their association with GD and GO. In total, 712 patients with GD with (n = 311) or without (n

SUBMITTER: Shahida B 

PROVIDER: S-EPMC6276746 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature