The Susceptibility Genes in Diabetic Nephropathy.

ABSTRACT:

Background

Diabetes mellitus (DM) poses a severe threat to global public health. Diabetic nephropathy (DN) is one of the most common complications of diabetes and the leading cause of end-stage renal disease (ESRD). Approximately 30-40% of DM patients in the world progress to ESRD, which emphasizes the effect of genetic factors on DN. Family clustering also supports the important role of hereditary factors in DN and ESRD. Therefore, a large number of genetic studies have been carried out to identify susceptibility genes in different diabetic cohorts. Extensive susceptibility genes of DN and ESRD have not been identified until recently.

Summary and key messages

Some of these associated genes function as pivotal regulators in the pathogenesis of DN, such as those related to gl

SUBMITTER: Wei L 

PROVIDER: S-EPMC6276750 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature