Structure-Function Relationships of Olfactory and Taste Receptors.

ABSTRACT: The field of chemical senses has made major progress in understanding the cellular mechanisms of olfaction and taste in the past 2 decades. However, the molecular understanding of odor and taste recognition is still lagging far behind and will require solving multiple structures of the relevant full-length receptors in complex with native ligands to achieve this goal. However, the development of multiple complimentary strategies for the structure determination of G protein-coupled receptors (GPCRs) makes this goal realistic. The common conundrum of how multi-specific receptors that recognize a large number of different ligands results in a sensory perception in the brain will only be fully understood by a combination of high-resolution receptor structures and functional studies. This revie

SUBMITTER: Behrens M 

PROVIDER: S-EPMC6276892 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature