Use of statins or NSAIDs and survival of patients with high-grade glioma.

ABSTRACT:

Background

High-grade glioma (HGG) is associated with a limited prognosis. Drug repurposing has become of increasing interest to improve standard therapy. Statins and NSAIDs inhibit glioma cell growth in vitro and in vivo, but data on statin and NSAID treatment in relation to survival of patients with HGG are sparse.

Methods

We performed multivariable adjusted Cox-regression analyses among 1,093 patients with HGG from a regional cancer registry to obtain Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) for overall survival (OS) and progression-free survival (PFS) according to treatment with statins or NSAIDs. Data on dose and duration of treatment was mostly lacking in our analysis, therefore we were not able to perform dose-response analyses.

Results

Use of st

SUBMITTER: Seliger C 

PROVIDER: S-EPMC6277074 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature