Injury of Adult Zebrafish Expressing Acvr1l^Q204D Does Not Result in Heterotopic Ossification.

ABSTRACT: Fibrodysplasia Ossificans Progressiva (FOP) is a rare, autosomal dominant genetic disorder in humans characterized by the gradual ossification of fibrous tissues, including skeletal muscle, tendons, and ligaments. In humans, mutations in the Type I BMP/TGFβ family member receptor gene, ACVR1, are associated with FOP. Zebrafish acvr1l, previously known as alk8, is the functional ortholog of human ACVR1. We previously created and characterized the first adult zebrafish model for FOP by generating animals harboring heat shock-inducible mCherry-tagged constitutively active Acvr1l (Q204D). Since injury is a known trigger for heterotopic ossification (HO) development in human FOP patients, in this study, we investigated several injury models in Acvr1l^Q204D-expressing zebrafish and the

SUBMITTER: LaBonty M 

PROVIDER: S-EPMC6277083 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature