Rosetta FunFolDes - A general framework for the computational design of functional proteins.

ABSTRACT: The robust computational design of functional proteins has the potential to deeply impact translational research and broaden our understanding of the determinants of protein function and stability. The low success rates of computational design protocols and the extensive in vitro optimization often required, highlight the challenge of designing proteins that perform essential biochemical functions, such as binding or catalysis. One of the most simplistic approaches for the design of function is to adopt functional motifs in naturally occurring proteins and transplant them to computationally designed proteins. The structural complexity of the functional motif largely determines how readily one can find host protein structures that are "designable", meaning that are likely to present the fun

SUBMITTER: Bonet J 

PROVIDER: S-EPMC6277116 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature