Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima.

ABSTRACT: Understanding the genetic basis of phenotypic adaptation to changing environments is an essential goal of population and quantitative genetics. While technological advances now allow interrogation of genome-wide genotyping data in large panels, our understanding of the process of polygenic adaptation is still limited. To address this limitation, we use extensive forward-time simulation to explore the impacts of variation in demography, trait genetics, and selection on the rate and mode of adaptation and the resulting genetic architecture. We simulate a population adapting to an optimum shift, modeling sequence variation for 20 QTL for each of 12 different demographies for 100 different traits varying in the effect size distribution of new mutations, the strength of stabilizing selection, a

SUBMITTER: Stetter MG 

PROVIDER: S-EPMC6277123 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature