Simulations of blood as a suspension predicts a depth dependent hematocrit in the circulation throughout the cerebral cortex.

ABSTRACT: Recent advances in modeling oxygen supply to cortical brain tissue have begun to elucidate the functional mechanisms of neurovascular coupling. While the principal mechanisms of blood flow regulation after neuronal firing are generally known, mechanistic hemodynamic simulations cannot yet pinpoint the exact spatial and temporal coordination between the network of arteries, arterioles, capillaries and veins for the entire brain. Because of the potential significance of blood flow and oxygen supply simulations for illuminating spatiotemporal regulation inside the cortical microanatomy, there is a need to create mathematical models of the entire cerebral circulation with realistic anatomical detail. Our hypothesis is that an anatomically accurate reconstruction of the cerebrocirculatory archi

SUBMITTER: Hartung G 

PROVIDER: S-EPMC6277127 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature