Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model.

ABSTRACT: The lipid matrix of the stratum corneum, the outermost skin layer, consists primarily of ceramides, cholesterol, and FFAs. These lipids form a trilayer long-periodicity phase (LPP) that is unique to this barrier. Knowledge about the LPP is essential in understanding the barrier function. Previous studies of LPP lipid models have identified the position of the major lipid classes and suggested that a large fraction of FFAs and the ceramide acyl chain are present in the central region. However, the precise arrangement, such as lipid subclass mixing (isolated or mixed) and ceramide conformation (extended or hairpin), remains unknown. Here, we deuterated FFAs and the ceramide acyl chain to study CD₂ and CH₂ interactions with Fourier-transform infrared spectroscopy. The ce

SUBMITTER: Beddoes CM 

PROVIDER: S-EPMC6277170 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature