Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge.

ABSTRACT: One of the major medical challenges of the twenty-first century is the treatment of incurable and fatal neurodegenerative disorders caused by misfolded prion proteins. Since the discovery of these diseases a number of studies have been conducted to identify small molecules for their treatment, however to date no curative treatment is available. These studies can be highly expensive and time consuming, but more recent experimental approaches indicate a significant application for yeast prions in these studies. We therefore used yeast prions to optimize previous high-throughput methods for the cheaper, easier and more rapid screening of natural extracts. Through this approach we aimed to identify natural yeast-prion inhibitors that could be useful in the development of novel treatment strate

SUBMITTER: Jennings LK 

PROVIDER: S-EPMC6277187 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature