Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile.

ABSTRACT:

Background

The prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction.

Objectives

We assessed a unique situation of individuals living in Northern Chile with data on lifetime arsenic exposure to evaluate the relationship between arsenic and T2D, and investigate possible interactions with BMI.

Methods

We analyzed data collected from October 2007-December 2010 from an arsenic-cancer case-control study. Information on self-reported weight, height, smoking, diet, and other factors were obtained. Diabetes was defined by self-reported physician-dia

SUBMITTER: Castriota F 

PROVIDER: S-EPMC6277209 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature