Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics.

ABSTRACT: The dynamics of cellular membranes is primarily determined by lipid species forming a bilayer. Proteins are considered mainly as effector molecules of diverse cellular processes. In addition to large assemblies of proteins, which were found to influence properties of fluid membranes, biological membranes are densely populated by small, highly mobile proteins. However, little is known about the effect of such proteins on the dynamics of membranes. Using synthetic peptides, we demonstrate that transmembrane helices interfere with the mobility of membrane components by trapping lipid acyl chains on their rough surfaces. The effect is more pronounced in the presence of cholesterol, which segregates from the rough surface of helical peptides. This may contribute to the formation or stabilizatio

SUBMITTER: Olsinova M 

PROVIDER: S-EPMC6277224 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature