Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils.

ABSTRACT: Obesity and diabetes implicate in various health complications and increased mortality caused by infection. Innate immune system is broadly affected by these diseases, leading the patients to an immunosuppressive state. A mechanism that leads innate immune cells to a less capacity of killing microorganism is the impaired TLR4 activation. TLR4 recognizes a component of the outer membrane of Gram-negative bacteria, lipopolysaccharide (LPS), and when activated increases the production of inflammatory substances. Neutrophils are components of the innate immune system and are the first responders to an invading agent. The correct activation of TLR4 in these cells is required for the initiation of the inflammatory process and elimination of the microorganisms. The aim of this study was to evalua

SUBMITTER: Kuwabara WMT 

PROVIDER: S-EPMC6277411 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature