Flexible Delivery Patch Systems based on Thermoresponsive Hydrogels and Submicronic Fiber Heaters.

ABSTRACT: This paper proposes a novel, flexible, low cost administration patch which could be used as a non-invasive, controlled transdermal drug delivery system. The fabricated device consists in a flexible microfiber architecture heater covered with a thermoresponsive hydrogel, namely poly(N-isopropylacrylamide), as a matrix for the incorporation of active molecules. The manufacturing process consists of two main steps. First, the electrospun poly(methyl methacrylate) fiber networks are sputter coated with a thin gold layer and attached to flexible poly(ethylene terephthalate) substrates to obtain the heating platforms. Second, the heaters are encapsulated in poly(ethylene terephthalate) foils and covered with poly(N-isopropylacrylamide) hydrogel sheets. In order to illustrate the functionality of

SUBMITTER: Evanghelidis A 

PROVIDER: S-EPMC6277443 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature