Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice.

ABSTRACT: Accumulating data demonstrated that hepatic endoplasmic reticulum (ER) stress was involved in the pathogenesis of liver fibrosis. Long-term chronic hepatocyte death contributed to liver fibrosis initiation and progression. Previous researches reported that ER stress sensor inositol-requiring enzyme 1 alpha (IRE1α) was first activated in the process of liver fibrosis. STF-083010 was an IRE1α RNase specific inhibitor. This study aimed to explore the effects of STF-083010 on carbon tetrachloride (CCl₄)-induced liver injury and subsequent liver fibrosis. Mice were intraperitoneally (i.p.) injected with CCl₄ (0.15 ml/kg) for 8 weeks. In STF-083010+CCl₄ group, mice were injected with STF-083010 (30 mg/kg, i.p.), twice a week, beginning from the 6th week after CCl

SUBMITTER: Chen QQ 

PROVIDER: S-EPMC6277551 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature