Genetic Polymorphisms of Catalase and Glutathione Peroxidase-1 in Keratoconus.

ABSTRACT:

Background

Keratoconus (KC) is a degenerative eye disease which results from thinning of the cornea and causes vision distortion. Oxidative stress damage to KC corneas may be because of the failure of corneas to process reactive oxygen species which leads to corneal thinning and loss of vision. Genetic variants in antioxidant defense genes such as catalase (CAT) and glutathione peroxidase (GPX) can decrease antioxidant capacity or increase oxidative stress and alter the risk of KC in patients. We investigated and evaluated the effects of single nucleotide polymorphisms in CAT, GPX-1 on the risk of KC in an Iranian population sample.

Methods

This case-control study was performed on 140 patients with KC and 150 healthy control subjects in a sample of Iranian population from Za

SUBMITTER: Yari D 

PROVIDER: S-EPMC6277734 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature