Identification of a First Human Norovirus CD8⁺ T Cell Epitope Restricted to HLA-A^*0201 Allele.

ABSTRACT: Norovirus (NoV) causes a substantial global burden of acute gastroenteritis in all age groups and the development of NoV vaccine is a high priority. There are still gaps in understanding of protective NoV-specific immunity. Antibody mediated immune responses have been widely studied, but in contrast, the research on NoV-specific human T cell-mediated immunity is very limited. We have recently reported NoV capsid VP1-specific 18-mer peptide (¹³⁴SPSQVTMFPHIIVDVRQL¹⁵¹) to induce strong CD8⁺ T cell immune responses in healthy adult donors. This work extends to identify the precise NoV T cell epitope and the restricting human leucocyte antigen (HLA). Pentamer technology was used to detect HLA-A^*0201-restricted T cell-mediated responses to 10-mer pepti

SUBMITTER: Malm M 

PROVIDER: S-EPMC6277766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature