Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3.

ABSTRACT: Estrogens have been shown to rapidly regulate local signalling at synapses and within the nucleus. The result of these signalling events is to rapidly modulate synapse structure and function, as well as epigenetic mechanisms including histone modifications. Ultimately these mechanisms are thought to contribute to long-lasting changes in neural circuitry, and thus influence cognitive functions such as learning and memory. However, the mechanisms by which estrogen-mediated local synaptic and nuclear signalling events are coordinated are not well understood. In this study we have found that the scaffold protein afadin, (also known as AF-6), undergoes a bi-directional trafficking to both synaptic and nuclear compartment in response to acute 17β-estradiol (estradiol) treatment, in mixed sex neu

SUBMITTER: Sellers KJ 

PROVIDER: S-EPMC6277849 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature