Protein Kinase C Inhibition Mediates Neuroblast Enrichment in Mechanical Brain Injuries.

ABSTRACT: Brain injuries of different etiologies lead to irreversible neuronal loss and persisting neuronal deficits. New therapeutic strategies are emerging to compensate neuronal damage upon brain injury. Some of these strategies focus on enhancing endogenous generation of neurons from neural stem cells (NSCs) to substitute the dying neurons. However, the capacity of the injured brain to produce new neurons is limited, especially in cases of extensive injury. This reduced neurogenesis is a consequence of the effect of signaling molecules released in response to inflammation, which act on intracellular pathways, favoring gliogenesis and preventing recruitment of neuroblasts from neurogenic regions. Protein kinase C (PKC) is a family of intracellular kinases involved in several of these gliogenic si

SUBMITTER: Garcia-Bernal F 

PROVIDER: S-EPMC6277931 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature