Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases.

ABSTRACT:

Background

DNA methylation plays a vital role in reproduction. Entire genome DNA methylation changes during the oestrous phase (ES) and dioestrous phase (DS) in the ovaries of Guanzhong dairy goats were investigated using bisulphite sequencing to understand the molecular biological mechanisms of these goats' oestrous cycle.

Results

We discovered distinct genome-wide DNA methylation patterns in ES and DS ovaries. A total of 26,910 differentially methylated regions were upregulated and 21,453 differentially methylated regions were downregulated in the ES samples compared with the DS samples (P-values ≤0.05 and fold change of methylation ratios ≥2). Differentially methylated region analysis showed hypomethylation in the gene body regions and hypermethylation in the joini

SUBMITTER: An X 

PROVIDER: S-EPMC6277999 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature