A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

ABSTRACT:

Background

The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research improved therapeutic strategies to combat renal cardiac pathologies. Murine in vivo models contribute greatly to such research allowing for specific genetic modification and reduced miscellany, however there is currently no reliable model of reno-cardiac syndrome in the most common genetically modified mouse strain, the C57BL/6. In this study we have manipulated an established model of chronic renal disease using adenine infused diet and prolonged the course of its patho

SUBMITTER: Kieswich JE 

PROVIDER: S-EPMC6278034 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature