Metabolic engineering of the thermophilic filamentous fungus Myceliophthora thermophila to produce fumaric acid.

ABSTRACT:

Background

Fumaric acid is widely used in food and pharmaceutical industries and is recognized as a versatile industrial chemical feedstock. Increasing concerns about energy and environmental problems have resulted in a focus on fumaric acid production by microbial fermentation via bioconversion of renewable feedstocks. Filamentous fungi are the predominant microorganisms used to produce organic acids, including fumaric acid, and most studies to date have focused on Rhizopus species. Thermophilic filamentous fungi have many advantages for the production of compounds by industrial fermentation. However, no previous studies have focused on fumaric acid production by thermophilic fungi.

Results

We explored the feasibility of producing fumarate by metabolically engineerin

SUBMITTER: Gu S 

PROVIDER: S-EPMC6278111 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature