Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study.

ABSTRACT:

Background

The genetics of fetal insulin release and/or action have been suggested to affect fetal growth, adult insulin resistance and adult body composition. The genetic correlation between body composition at birth versus glycaemic regulation and body composition in adulthood have, however, not been well studied. We therefore aimed to investigate these genetic correlations in a family-based cohort.

Methods

A Danish family cohort of 434 individuals underwent an oral glucose tolerance test with subsequent calculation of surrogate measures of serum insulin response and insulin sensitivity. Measures of fetal growth were retrieved from midwife journals. Heritability and genetic correlations were estimated using a variance component model.

Results

A high heritability of

SUBMITTER: Hollensted M 

PROVIDER: S-EPMC6278142 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature