RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer.

ABSTRACT:

Background

RNA binding proteins (RBPs) play an important role in regulating the metabolism of target RNAs. Aberrant expression of RBPs plays a vital role in the initiation and development of many cancers. The RBM family, which has the conserved RNA binding motif RNP1 and RNP2, shares the similar function in RNA processing and RBMS2 is a member of them. P21, also named CDKN1A, promotes cell cycle arrest and plays an important role in halting cell proliferation. In our study, we identified RBMS2 as a tumor suppressor in breast cancer. It inhibited the proliferation of breast cancer by positively regulating the stability of P21 mRNA in posttranscriptional way.

Methods

TCGA was used to identify differentially expressed RBPs in breast cancer. The effect of RBMS2 on breast cancer

SUBMITTER: Sun X 

PROVIDER: S-EPMC6278172 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature