Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions.

ABSTRACT: The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence motifs, dynamic interactions, or conformational heterogeneity, which facilitate the decision-making in regulatory processes, ranging from enzymes to membraneless cellular compartments. The fuzzy set theory offers a quantitative framework to address these problems. The fuzzy formalism allows the simultaneous involvement of proteins in multiple activities, the degree of which is given by the corresponding memberships. Adaptation is described via a fuzzy inference system, which relates heterogeneous conformational ensembles to different biological activi

SUBMITTER: Fuxreiter M 

PROVIDER: S-EPMC6278454 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature