Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures.

ABSTRACT: Nucleoside analogues have found widespread application as antiviral and antitumor agents, but not yet as antibacterials. Naturally occurring uridine-derived 'nucleoside antibiotics' target the bacterial membrane protein MraY, an enzyme involved in peptidoglycan biosynthesis and a promising target for the development of novel antibacterial agents. Muraymycins represent a nucleoside-peptide subgroup of such MraY-inhibiting natural products. As part of detailed structure-activity relationship (SAR) studies on muraymycins and their analogues, we now report novel insights into the effects of stereochemical variations in the nucleoside core structure. Using a simplified version of the muraymycin scaffold, it was shown that some formal inversions of stereochemistry led to about one order of magni

SUBMITTER: Spork AP 

PROVIDER: S-EPMC6278576 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature