Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study.

ABSTRACT:

Objective

To determine whether use of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists are associated with an increased risk of cholangiocarcinoma in adults with type 2 diabetes.

Design

Population based cohort study.

Setting

General practices contributing data to the UK Clinical Practice Research Datalink.

Participants

154 162 adults newly treated with antidiabetic drugs between 1 January 2007 and 31 March 2017, followed until 31 March 2018.

Main outcome measures

Use of DPP-4 inhibitors and GLP-1 receptor agonists was modelled as a time varying variable and compared with use of other second or third line antidiabetic drugs. All exposures were lagged by one year to account for cancer latency and to minimise r

SUBMITTER: Abrahami D 

PROVIDER: S-EPMC6278586 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature