Time- and frequency-domain measures of heart rate variability predict cardiovascular outcome in patients with type 2 diabetes.

ABSTRACT:

Aims

To evaluate the association between impaired heart rate variability (HRV) and cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM).

Methods

A total of 655 patients with T2DM who underwent cardiovascular autonomic function testing were consecutively recruited and followed up prospectively. Time- and frequency-domain HRV were assessed for 5 min by beat-to-beat heart rate recording. We estimated the development of CVD events during a follow-up period.

Results

During a median follow-up of 7.8 years, 9.6% (n = 49) of patients developed CVD (10.6 per 1000 patient-years). The mean age and diabetes duration were 54.9 ± 8.6 years and 9.4 ± 7.3 years, respectively. Patients who had cardiovascular autonomic neuropathy (CAN) had decreased HRV compared with th

SUBMITTER: Cha SA 

PROVIDER: S-EPMC6278593 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature