P53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice.

ABSTRACT: Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Among animal models, mouse mutants are particularly valuable since they allow conjoint behavioral, organismal, and genetic analyses. Along with this, since aging has been associated with higher frequency of seizures, prematurely aging mice, simulating human progeroid diseases, offer a further useful modeling element as they recapitulate aging over a short time-window. Here we report on a mouse mutant with progeroid traits that displays repeated spontaneous seizures. Mutant mice

SUBMITTER: Burla R 

PROVIDER: S-EPMC6278696 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature